Patients taking a norepinephrine-dopamine reuptake inhibitor such as Wellbutrin (bupropion) are at risk for:

A. Circulatory disorder: Bupropion does not commonly cause major circulatory disorders. While it can slightly increase blood pressure in some patients, serious cardiovascular events are rare and not the primary concern. B. Seizures: Bupropion lowers the seizure threshold, especially at higher doses or in patients with a history of seizure disorders, eating disorders, or abrupt alcohol withdrawal. This is a well-documented and clinically significant adverse effect that requires careful monitoring. C. Sedation: Bupropion is generally activating rather than sedating. Patients may experience insomnia or restlessness rather than drowsiness, making sedation an uncommon side effect. D. Vomiting: Gastrointestinal side effects, including nausea, can occur with bupropion, but vomiting is not a primary or severe risk. Seizure risk remains the main serious adverse effect to monitor.