Select all the TRUE statements about the pathophysiology of multiple sclerosis: (Select All that Apply.)

A. Multiple sclerosis (MS) affects myelin in the central nervous system (CNS)—the brain and spinal cord—not the peripheral nervous system. Disorders affecting peripheral myelin are classified as peripheral neuropathies, such as Guillain-Barré syndrome. B. In MS, the myelin sheath along axons is damaged due to an autoimmune response. This demyelination slows or blocks nerve signal conduction, leading to neurological deficits such as weakness, sensory changes, and visual disturbances. C. MS is a chronic inflammatory autoimmune disorder in which the body’s immune system attacks the myelin sheath, causing inflammation, demyelination, and eventual axonal damage. The disease course is typically relapsing-remitting or progressive. D. MS specifically targets the insulating structure (myelin) on neurons in the CNS, disrupting the ability of neurons to efficiently transmit electrical impulses. Damage to the CNS myelin, rather than peripheral myelin, is the hallmark of the disease.