Select the correct antibody with its function.(Select all that apply)

A. IgD – Attaches to mast cells and basophils on epithelial surfaces and enhances release of histamine and other vasoactive mediators responsible for the "wheal and flare" reaction. Important for allergic responses, inflammatory reactions, and parasitic infections. B. IgA – Found on mucosal surfaces of respiratory, GI, and GU systems, preventing antigen adherence. Influential against bacteria and some viral organisms. Does not cross the placenta but passes to newborn through colostrum and breast milk. Deficiency may be congenital (autosomal dominant or recessive) or related to anticonvulsant use. C. IgM – First antibody formed after exposure to an antigen, rapidly diminishes as IgG increases. Present mostly in the intravascular space. Causes antigenic agglutination and cell lysis via complement activation. D. IgG- Produced primarily by T-cells in the bone marrow to stimulate the production of red blood cells. It is the only antibody that cannot cross the placental barrier, ensuring the fetus remains unprotected from maternal infections until after birth. E. IgE- The most abundant antibody in the blood, making up 80% of total serum. It functions mainly as a receptor on B-lymphocytes to regulate the secretion of insulin from the pancreas during an immune response.