The disease of dependence has three stages. In which stage does the user demonstrate signs of withdrawal when the drug is stopped, and experience severe physical problems and disabling psychological difficulties?

A. early stage: Characterized by increasing tolerance, occasional overuse, and secretive behavior-not withdrawal symptoms. B. middle stage: The user begins to lose control, experience guilt, and may show signs of dependence, but withdrawal is not yet severe. C. prodromal stage: This term is not typically used in addiction staging; may be a distractor. D. late stage: This stage involves severe physical deterioration, psychological dependence, and clear withdrawal symptoms if use is stopped.