The healthcare provider is planning to prescribe Buprenorphine (Suboxone) for a patient diagnosed with an opioid use disorder. What assessment observations support the appropriateness of the intervention? SELECT 3

A. Patient is diaphoretic: Diaphoresis is a classic sign of opioid withdrawal, indicating the patient is in an appropriate phase for buprenorphine initiation. Administering buprenorphine during active withdrawal reduces the risk of precipitated withdrawal. B. Patient reports being "constipated for nearly one week": Opioid-induced constipation is a common withdrawal symptom and marker of opioid dependence. This supports the need for a partial opioid agonist like buprenorphine to manage withdrawal while minimizing abuse potential. C. Patient reports a headache that has lasted 12 hours: A headache alone is nonspecific and may be unrelated to opioid use disorder or withdrawal. It does not provide sufficient evidence to support initiating buprenorphine therapy. D. Erythema noted about the face, neck, and upper trunk: Flushing and erythema are frequent autonomic signs during opioid withdrawal, indicating sympathetic overactivity. These findings further confirm that the patient is in a physiologic state appropriate for buprenorphine administration.