The healthcare provider prescribes ampicillin 140 mg intravenously (IV) every 8 hours for a child with meningitis. The vial is labeled, "Ampicillin 250 mg for reconstitution with 8.3 mL sterile normal saline for injection to yield a total solution concentration of 30 mg/mL." How many mL should the nurse administer? (Enter the numeric value only. If rounding is required, round to the nearest tenth.)
Explanation & Rationale
Here's how to calculate the volume (mL) of the reconstituted ampicillin solution the nurse should administer for each dose: 1. We know the following: Prescribed dose: 140 mg ampicillin (given) Vial information: Contains 250 mg ampicillin powder (given) Reconstituted with 8.3 mL sterile normal saline (given) Yields a final concentration of 30 mg/mL (given) 2. We need to find the volume (mL) of the reconstituted solution containing the prescribed dose (140 mg) considering the final concentration (30 mg/mL). Steps: a. Don't consider the initial volume (8.3 mL) of sterile normal saline. The final concentration (30 mg/mL) refers to the concentration in the diluted solution after adding the saline. b. Use the following formula: Volume to administer (mL) = Dose (mg) / Concentration (mg/mL) c. Plug in the values: Volume to administer (mL) = 140 mg / 30 mg/mL Volume to administer (mL) = 4.67 mL (round to nearest tenth) Therefore, the nurse should administer approximately 4.7 mL of the reconstituted ampicillin solution intravenously every 8 hours for the child.