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    Hesi pharmacology proctored exam

    The healthcare provider prescribes propylthiouracil (PTU) and Lugol's solution, a strong iodine solution, for a client with hyperthyroidism. How should the nurse schedule the administration of these medications?

    Explanation & Rationale

    A. Give parental dose once every 24 hours: PTU is usually administered orally multiple times daily to maintain steady therapeutic levels. A single parenteral dose every 24 hours does not reflect standard dosing for hyperthyroidism management. B. Schedule both medications at bedtime: Administering both PTU and iodine at bedtime does not optimize their pharmacologic effects. Proper timing based on absorption and action is important, rather than simply giving medications at bedtime. C. Offer both drugs together with a meal: While giving medications with food can reduce gastrointestinal upset, administering PTU and iodine simultaneously may reduce iodine’s effectiveness. They should be timed appropriately to avoid interference with each other’s absorption. D. Administer iodine one hour before PTU: Giving iodine one hour before PTU helps maximize iodine’s ability to inhibit thyroid hormone release before PTU blocks hormone synthesis. This scheduling enhances the overall effectiveness of hyperthyroidism treatment.

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