The LPN/LVN is aware that the bioavailability of a drug is based on multiple factors. Which factor(s) would be included? Select all that apply.

A. Molecular weight: Drugs with lower molecular weight tend to have higher bioavailability because they can more easily pass through biological membranes. B. Fat or liquid solubility: Drugs that are fat-soluble can cross cell membranes more easily, affecting their bioavailability. Water-soluble drugs may require transport mechanisms, which can limit absorption. C. Depth of breathing: The depth of breathing primarily affects the absorption of inhaled drugs, not the general bioavailability of orally or intravenously administered medications. D. Development of a fever: While fever can affect drug metabolism, it doesn’t directly influence the bioavailability of a drug. E. Presence of food: Food in the stomach can either enhance or inhibit drug absorption, depending on the drug’s characteristics. This directly impacts bioavailability.