The nurse administered insulin lispro to a client 45 minutes ago. Which finding should cause the nurse to assess for hypoglycemia?

A. The client reports increased hunger: Hunger can occur as blood glucose begins to fall, but it is an early and nonspecific adrenergic sign and may not reliably indicate clinically significant hypoglycemia. It requires monitoring but is less urgent than symptoms linked to neuroglycopenia or autonomic overactivation. B. The client reports palpitations: Palpitations reflect sympathetic nervous system activation due to rapid declines in plasma glucose, triggering catecholamine release. This response occurs during acute hypoglycemia and signals that glucose levels may be dropping to a dangerous range, requiring immediate assessment and intervention. C. The client reports a headache: Headache may develop with hypoglycemia but tends to occur later as neuroglycopenia progresses. It is less specific and does not usually precede severe or acute hypoglycemic episodes as reliably as adrenergic symptoms such as palpitations or tremors. D. The client reports joint pain: Joint pain is not physiologically associated with hypoglycemia and is unrelated to insulin’s metabolic effects. It does not reflect glucose fluctuations or autonomic activation and therefore would not prompt hypoglycemia assessment.