The nurse assesses a client admitted with advanced cirrhosis of the liver. Which laboratory results are consistent with the disease process? Select all that apply.

Rationale: A. In advanced cirrhosis, the liver’s synthetic function is impaired, leading to decreased production of albumin. Low albumin contributes to ascites, peripheral edema, and decreased oncotic pressure. A value of 7.2 g/dL is well above the normal range and is inconsistent with cirrhosis, making this an unlikely finding in this disease process. B. Thrombocytopenia is a common finding in cirrhosis due to multiple mechanisms. Portal hypertension causes splenic enlargement (splenomegaly) and sequestration of platelets, while impaired liver function decreases thrombopoietin production, reducing platelet formation. A platelet count of 75,000 cells/mm³ reflects significant reduction and is consistent with advanced liver disease. C. Amylase is an enzyme produced primarily by the pancreas and salivary glands. While levels may be slightly elevated in pancreatic disorders, it is not a specific or consistent marker of liver dysfunction. A value of 200 units/L is within or near the normal range and does not correlate with cirrhosis. D. Elevated ammonia occurs in cirrhosis because the damaged liver cannot efficiently convert ammonia to urea, leading to accumulation in the blood. High ammonia levels are associated with hepatic encephalopathy, causing confusion, altered mental status, and other neurologic symptoms. A value of 96 mcg/dL is above the normal range and consistent with advanced liver disease. E. The liver synthesizes most clotting factors, so impaired hepatic function in cirrhosis leads to coagulopathy, reflected as a prolonged prothrombin time (PT). A PT of 22 seconds indicates significant impairment of the clotting cascade, which is a common complication of advanced cirrhosis.