The nurse assesses a client taking cyclosporine following a kidney transplant. Which finding is most concerning to the nurse?

Rationale: A. Occasional nausea after taking cyclosporine is a common, mild side effect of the medication and is not usually a sign of serious complications. This can often be managed by taking the medication with food or adjusting the administration schedule. B. A nontender lump in the right groin is most concerning because cyclosporine is an immunosuppressant, which increases the risk of infections and malignancies, including lymphoproliferative disorders. A new lump could indicate an infection, abscess, or post-transplant lymphoproliferative disorder (PTLD), all of which require immediate evaluation. Early detection is critical to prevent serious complications. C. Bleeding of the gums while brushing is a known minor side effect of cyclosporine due to gingival hyperplasia. Although it can be bothersome, it is not usually life-threatening and can often be managed with good oral hygiene and dental care. D. Numbness and tingling of the feet may indicate peripheral neuropathy, which can occur with cyclosporine but is typically gradual and chronic rather than an acute concern. While it should be monitored, it is less immediately concerning than a potential sign of infection or malignancy.