The nurse is administering clozapine to a client diagnosed with schizophrenia. Which symptoms require the nurse to intervene immediately?

Choice A reason: Akathisia (a feeling of inner restlessness) and hypersalivation are known side effects of clozapine but are not immediately life-threatening. These symptoms may require monitoring or dose adjustment but do not warrant urgent intervention unless they severely impair functioning. Choice B reason: Sore throat, fever, and malaise are signs of agranulocytosis, a potentially fatal adverse effect of clozapine. Agranulocytosis involves a dangerously low white blood cell count, increasing the risk of severe infection. These symptoms require immediate intervention, including discontinuation of the drug and urgent blood work to assess neutrophil levels. Choice C reason: Dry mouth and urinary retention are anticholinergic side effects that may cause discomfort but are not immediately dangerous. They can be managed with supportive care and do not require urgent discontinuation of the medication. Choice D reason: Akinesia (loss of voluntary movement) and insomnia may be distressing but are not emergent. These symptoms may indicate extrapyramidal side effects or poor sleep hygiene, which can be addressed through medication adjustment or behavioral strategies.