The nurse is caring for a client prescribed tetracycline. Which question(s) should the nurse ask when evaluating a client's response to the drug? Select all that apply.

A. "Have your bowel movements changed?": Tetracycline can disrupt normal gut flora and lead to diarrhea or, rarely, antibiotic-associated colitis. Assessing bowel patterns helps identify gastrointestinal adverse effects early. B. "Have you had any nausea or vomiting?": Gastrointestinal upset, including nausea and vomiting, is a common side effect of tetracycline. Asking about these symptoms evaluates tolerance and guides supportive care measures. C. "Is that rash on your upper arm new?": Tetracycline can cause dermatologic reactions, including photosensitivity rashes. Monitoring for new or worsening rashes helps detect adverse reactions promptly. D. "Have your herpes lesions improved?": Tetracycline is an antibacterial medication and has no effect on viral infections like herpes. Improvement of herpes lesions is not relevant when evaluating tetracycline efficacy. E. "What symptoms are you experiencing?": A general symptom inquiry allows the nurse to capture both expected therapeutic effects and adverse reactions. This open-ended approach ensures comprehensive assessment of the client’s response.