The nurse is caring for a patient who has diabetes and reports chronic, burning leg pain even when taking oxycodone (OxyContin) twice daily. Which prescribed medication is the best choice for the nurse to administer as an adjuvant to decrease the patient's pain?

Rationale: A. Amitriptyline, a tricyclic antidepressant, is frequently used as an adjuvant analgesic for neuropathic pain, such as diabetic neuropathy. It works by modulating neurotransmitters that influence pain perception. B. Aspirin is an NSAID useful for inflammation or mild pain but not effective for neuropathic pain. C. Celecoxib is a COX-2 inhibitor NSAID, effective for inflammatory pain (like arthritis), but not neuropathic pain. D. Acetaminophen is an analgesic and antipyretic but has no significant effect on neuropathic pain.