The nurse is educating parents on the genetic inheritance of hemophilia What response by the parents of the client determines they have understood the education?

Choice A rationale Hemophilia A is an X-linked recessive bleeding disorder caused by a deficiency in functional Factor VIII, a protein essential for the clotting cascade. Because the gene is on the X chromosome, males (XY) are primarily affected when they inherit the defective X, while females (XX) are typically carriers unless they inherit two defective X chromosomes, which is rare. Choice B rationale X-linked dominant inheritance means only one copy of the defective gene on the X chromosome is needed to express the trait. If hemophilia A were X-linked dominant, affected fathers would pass the disorder to all of their daughters, and affected mothers would have a 50 percent chance of passing it to any child, which is not the typical pattern for hemophilia A. Choice C rationale Y-linked traits are passed directly from father to son because the gene is located on the Y chromosome. Hemophilia A does not follow this inheritance pattern as it affects males and females can be carriers, demonstrating that the gene is not solely on the Y chromosome but the X chromosome. Choice D rationale A Y-linked dominant trait would mean the gene is on the Y chromosome and only one copy is needed for expression, similar to recessive. Like Y-linked recessive, this would only affect males and would be passed directly from father to son, which is inconsistent with the known X-linked inheritance of hemophilia A.