The nurse is planning an educational program on sildenafil to a group of older male clients. Which of the following information should the nurse include in the educational program?

A. Sildenafil, when taken with nitrates (like nitroglycerin), can cause severe hypotension due to additive vasodilation. Clients should be warned against concurrent use. B. A high-fat meal can delay the absorption of sildenafil, reducing its effectiveness—not increase it. C. Sildenafil is typically taken about 30 to 60 minutes before sexual activity, not 2 hours. D. Grapefruit juice can interfere with liver metabolism of sildenafil, potentially increasing the risk of adverse effects. It should be avoided.