The nurse is planning discharge instructions for a client with type 2 diabetes mellitus who will be starting exenatide. Which information should be included in the discharge instructions?
Explanation & Rationale
A. Inject exenatide within 30 minutes before or after a meal: Exenatide should be injected within 60 minutes before the morning and evening meals, not after, to mimic natural incretin hormone activity and optimize glucose control. B. There are no precautions about taking exenatide with other medications: Exenatide can delay gastric emptying, which may affect the absorption of oral medications, especially antibiotics or contraceptives, so timing and interactions must be considered. C. Exenatide acts in the same way as insulin in lowering blood glucose: Exenatide is not insulin; it is a GLP-1 receptor agonist that stimulates insulin release in response to meals and suppresses glucagon—its mechanism is different from direct insulin replacement. D. Notify your healthcare provider if you start having abdominal pain: Severe abdominal pain may indicate pancreatitis, a rare but serious adverse effect of exenatide, and should be reported immediately for evaluation and possible discontinuation of the medication.