The nurse is preparing a teaching tool about oral delayed release proton pump inhibitors used to treat duodenal ulcer disease caused by H. pylori. Which statement will the nurse include in their teaching?

A. Abdominal pain and abnormal liver function tests are expected effects: While rare side effects like abdominal discomfort or liver enzyme elevations can occur, they are not expected or common. Clients should report such symptoms promptly. B. The medication is to be swallowed whole and taken before meals: Delayed-release PPIs (e.g., omeprazole, lansoprazole) must be swallowed whole to preserve the enteric coating that protects the drug from stomach acid. They should be taken before meals for optimal acid suppression when the proton pumps are most active. C. May cause proctitis: Proctitis (inflammation of the rectum) is not a recognized side effect of oral proton pump inhibitors. This side effect is unrelated to PPI therapy and is more often associated with infections, radiation, or inflammatory bowel diseases. D. Do not take with alcohol or any other CNS depressants: PPIs do not have CNS depressant effects and do not interact significantly with alcohol or CNS depressants. While limiting alcohol is generally advisable for gastrointestinal health, it is not specific to PPI use.