The nurse is providing an in-service on non-steroidal anti-inflammatory drugs (NSAIDs). Which of the following medications is a first-generation NSAID that inhibits both COX-1 and COX-2 enzymes?

Rationale A. Celecoxib is a second-generation NSAID that specifically inhibits COX-2 enzymes and is less likely to cause gastrointestinal side effects compared to first-generation NSAIDs. B. Morphine sulfate is an opioid analgesic and does not have NSAID properties. It works by binding to opioid receptors to relieve pain. C. Metformin is an oral medication used to manage blood glucose in type 2 diabetes and is not an NSAID. D. Ibuprofen is a first-generation NSAID that inhibits both COX-1 and COX-2 enzymes, reducing pain, inflammation, and fever.