The nurse is reinforcing medication teaching with a client. The nurse explains that side effects are most likely to occur.

A. At the start of medication therapy: Side effects are most common when a client first begins taking a new medication because the body is not yet accustomed to the drug. Over time, tolerance may develop, and some side effects may diminish. B. When clients take medication on an empty stomach – Some medications cause more side effects when taken on an empty stomach (e.g., NSAIDs causing gastritis), but this is not true for all medications. C. When clients take high doses of medication – Higher doses may increase the risk of toxicity rather than routine side effects. D. When clients take multiple medications – Drug interactions are more likely when taking multiple medications, but this does not mean that side effects are most common in this situation.