The nurse is using the CAGE questionnaire as a screening tool for a client who is seeking help because his wife said he had a drinking problem. Which information should the nurse explore in-depth with the client based on this screening tool?

A. While liver enzymes and gastrointestinal complaints are important, they are not part of the CAGE questionnaire. B. Cancer screening results, anger, and gastritis are not directly addressed by the CAGE questionnaire. C. The listed items are relevant but not specifically addressed by the CAGE questionnaire. D. Efforts to cut down, annoyance with questions, guilt, and drinking as an "eye-opener" are aspects explored in the CAGE questionnaire to assess alcohol dependency.