The nurse knows that which of the following antibiotics are resistant to beta-lactamase bacteria? Select all that apply, one, some, or all may be correct.

A. Ceftaroline.: Ceftaroline is a fifth-generation cephalosporin that is resistant to many beta-lactamase–producing bacteria. It has broad-spectrum activity and is notably effective against methicillin-resistant Staphylococcus aureus (MRSA) and certain gram-negative organisms. B. Ampicillin.: Ampicillin alone is not resistant to beta-lactamase–producing bacteria. It is easily inactivated by beta-lactamase enzymes secreted by resistant organisms, which limits its effectiveness unless combined with a beta-lactamase inhibitor. C. Amoxicillin/Clavulanic acid.: This combination is resistant to beta-lactamase because clavulanic acid is a beta-lactamase inhibitor. It prevents bacterial enzymes from destroying the beta-lactam ring of amoxicillin, allowing the antibiotic to remain active against resistant strains. D. Piperacillin/tazobactam.: Piperacillin combined with tazobactam also gains resistance to beta-lactamase enzymes. Tazobactam inhibits beta-lactamase activity, enhancing piperacillin’s effectiveness against many gram-positive and gram-negative bacteria, including Pseudomonas aeruginosa.