The Nurse Practitioner knows which of the following is a common non-life threatening symptom associated with opioid withdrawal:

A. Abdominal cramps: Opioid withdrawal causes autonomic nervous system hyperactivity due to abrupt removal of opioid suppression. This leads to increased gastrointestinal motility, resulting in abdominal cramping, diarrhea, and nausea. These symptoms are uncomfortable but not life-threatening. B. Peripheral neuropathy: Peripheral neuropathy is associated with chronic metabolic, toxic, or nutritional conditions rather than acute opioid withdrawal. Opioid withdrawal affects autonomic and gastrointestinal systems rather than peripheral nerve integrity. This finding does not align with withdrawal physiology. C. Pupil constriction: Opioid withdrawal is characterized by sympathetic overstimulation, leading to pupil dilation rather than constriction. Miosis is associated with opioid intoxication, not withdrawal. Eye findings help differentiate overdose from withdrawal states. D. Constipation: Constipation is a common adverse effect of ongoing opioid use due to reduced gastrointestinal motility. During withdrawal, bowel activity increases instead of slowing. This finding reflects opioid presence rather than opioid absence.