The pathophysiology of Parkinson's disease includes which of the following? (Select all that apply.)

A. A deficiency of the neurotransmitter dopamine: Parkinson’s disease results from the progressive degeneration of dopaminergic neurons in the substantia nigra, leading to dopamine deficiency. This loss disrupts the balance between dopamine and acetylcholine, causing motor symptoms such as tremors, rigidity, and bradykinesia. B. An accumulation of Lewy Bodies, especially in the basal ganglia: Lewy bodies, which are abnormal aggregates of alpha-synuclein protein, accumulate in nerve cells of the basal ganglia and other brain regions. Their presence interferes with neuronal function and contributes to the progressive neurodegeneration seen in Parkinson’s disease. C. A reduction of dopamine receptors: As dopaminergic neurons degenerate, there is also a decrease in the number and sensitivity of dopamine receptors in the striatum. This further reduces dopamine signaling and exacerbates motor impairment. D. The presence of neurofibrillary tangles and amyloid plaques in the brain: These pathological features are characteristic of Alzheimer’s disease, not Parkinson’s disease. They primarily affect memory and cognitive regions rather than the motor control centers involved in Parkinson’s. E. An inability of the neurons to absorb dopamine: The issue in Parkinson’s disease is not the absorption of dopamine but rather its insufficient production and release due to neuronal loss. Dopamine reuptake mechanisms remain largely intact early in the disease.