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    Pharmacology proctored examexamplify (MCPHS university)

    The patient who is taking atorvastatin develops yellowing of the skin, abdominal pain in the right upper quadrant, and nausea. Which lab results below correlates with this finding?

    Explanation & Rationale

    A. Decreased hemoglobin (Hb): A low hemoglobin level may indicate anemia but does not correlate with jaundice, right upper quadrant pain, or nausea. These symptoms point to hepatic dysfunction rather than a hematologic issue. B. Decreased white blood cell (WBC): A decreased WBC count could suggest bone marrow suppression or infection risk, but it is unrelated to liver injury. Statin-induced hepatotoxicity is not associated with leukopenia. C. Elevated BUN and creatinine: Elevated renal markers suggest kidney dysfunction, not liver injury. Atorvastatin is primarily associated with hepatotoxicity rather than nephrotoxicity, and the clinical signs described align more with liver involvement. D. Elevated ALT and AST level: ALT and AST are liver enzymes that rise in response to hepatocellular injury. Yellowing of the skin (jaundice), nausea, and right upper quadrant pain are classic signs of liver dysfunction, making this finding the most consistent with statin-induced hepatotoxicity.

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