The provider prescribes venlafaxine (Effexor) for depression. The nurse understands that this is a SNRI (Serotonin-Norepinephrine Reuptake Inhibitor). Which statements by the patient indicate that teaching was effective? (Select all that apply)

Choice A reason: This is correct. Abruptly discontinuing venlafaxine can lead to withdrawal symptoms such as agitation, headache, nausea, dizziness, and sensory disturbances. Patients should be educated to taper the dose under medical supervision to avoid discontinuation syndrome. Choice B reason: This is incorrect. Antidepressants like venlafaxine require consistent use over time to maintain therapeutic effects. Stopping the medication prematurely, even if the patient feels better, can lead to relapse or recurrence of depressive symptoms. Patients should be advised to consult their provider before making any changes. Choice C reason: This is incorrect. Unlike lithium or certain anticonvulsants, venlafaxine does not require routine blood level monitoring. Its therapeutic effect is monitored through clinical assessment of symptom improvement and side effects, not serum levels. Choice D reason: This is correct. Common side effects of venlafaxine, especially during initiation, include nausea, dizziness, dry mouth, and insomnia. Educating the patient about these expected effects helps promote adherence and reduces anxiety about the medication. Choice E reason: This is correct. Like most antidepressants, venlafaxine may take 2–4 weeks or longer to show noticeable improvement in mood. Patients should be informed about this delay to set realistic expectations and encourage adherence during the initial treatment phase.