Treatment for rheumatoid arthritis includes all of the following? Multiple options may be correct

A. Corticosteroids: Corticosteroids, such as prednisone, are used in rheumatoid arthritis (RA) to rapidly reduce inflammation and suppress the immune response. They are particularly useful for acute flares or bridging therapy while slower-acting disease-modifying drugs take effect. B. Disease-modifying antirheumatic drugs (DMARDs): DMARDs, including methotrexate, sulfasalazine, and hydroxychloroquine, target the underlying autoimmune processes in RA, slowing disease progression and preventing joint destruction. They form the cornerstone of long-term management. C. Methotrexate: Methotrexate is a first-line DMARD for RA, inhibiting dihydrofolate reductase and modulating the immune system. It effectively reduces synovial inflammation, slows radiographic progression, and improves functional outcomes in patients with moderate-to-severe disease. D. Allopurinol: Allopurinol is used to lower uric acid levels in gout, not RA. It does not affect the autoimmune inflammation or joint destruction characteristic of rheumatoid arthritis, so it is not part of standard RA therapy. E. Alendronate: Alendronate is a bisphosphonate used to treat osteoporosis by inhibiting osteoclast-mediated bone resorption. While RA patients may have secondary osteoporosis, alendronate does not treat the autoimmune or inflammatory processes of RA. F. Doxycycline: Doxycycline is an antibiotic with anti-inflammatory properties sometimes used experimentally in early RA for its matrix metalloproteinase inhibition, but it is not a standard treatment and is not considered a primary therapy for rheumatoid arthritis.