What are examples of opiates? (Select all that applies)

A. Morphine: Morphine is a naturally occurring opiate derived from the opium poppy and is the prototype for all opioid analgesics. It acts directly on opioid receptors to produce analgesia and euphoria. B. Methadone: Methadone is a synthetic opioid, not a natural opiate. Although it binds to the same receptors, it is chemically manufactured and not derived from opium. C. Heroin: Heroin (diacetylmorphine) is a semi-synthetic opiate derived from morphine. It crosses the blood-brain barrier rapidly, leading to intense euphoric effects. D. Codeine: Codeine is a naturally occurring opiate alkaloid found in the opium poppy. It is commonly used for mild to moderate pain and as a cough suppressant.