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    ATI Advanced Pharmacology Final Proctored Exam

    What class of antiarrhythmic drugs blocks potassium channels prolonging phase 3 of the action potential and slowing the rate and conduction of the heart?

    Explanation & Rationale

    Choice A rationaleClass I antiarrhythmic drugs block sodium channels, affecting phase 0 of the action potential, not phase 3.Choice B rationaleClass IV antiarrhythmic drugs block calcium channels, which affects phase 2 of the action potential and slows heart rate and conduction.Choice C rationaleClass III antiarrhythmic drugs block potassium channels, prolonging phase 3 of the action potential. This results in a prolonged repolarization period, reducing the risk of arrhythmia.Choice D rationaleClass II antiarrhythmic drugs are beta-blockers that primarily affect phase 4 of the action potential, reducing heart rate and conduction, but they do not block potassium channels.

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