What is a common side effect of Glipizide that patients should be aware of?

Rationale: A. Hypoglycemia: Glipizide is a sulfonylurea that stimulates insulin release from pancreatic beta cells, which can significantly lower blood glucose levels. This makes hypoglycemia the most common and clinically important side effect patients need to watch for. B. Weight gain: Weight gain can occur with glipizide use because of increased insulin activity, but it is not the most common or immediate side effect. Hypoglycemia is more frequent and requires greater patient education and monitoring. C. Constipation: Constipation is not typically associated with glipizide therapy. Gastrointestinal side effects, if present, are usually mild and less significant compared to the risk of hypoglycemia. D. Hypertension: Glipizide does not commonly cause hypertension. Blood pressure changes are not a notable side effect of sulfonylureas, making this effect less relevant compared to hypoglycemia.