What is an indication for glucagon-like peptide-1 (GLP-1) agonists?
Explanation & Rationale
A. Hypersensitivity to the drug: A history of hypersensitivity is a contraindication for GLP-1 agonists rather than an indication. Administering the drug to someone with an allergy could trigger severe allergic reactions, including anaphylaxis. B. Gastroparesis: GLP-1 agonists can slow gastric emptying, which may worsen gastroparesis symptoms. Therefore, gastroparesis is a precaution, not an indication, for using this class of medications. C. Medullary thyroid carcinoma: A personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 is a contraindication for GLP-1 agonists due to potential increased risk of thyroid tumors. D. Type 2 diabetes: GLP-1 agonists are indicated for managing type 2 diabetes as they enhance glucose-dependent insulin secretion, slow gastric emptying, and promote satiety, helping improve glycemic control and support weight management.