What is the direct effect of mediators released during the inflammatory response in SIRS?

A. Decreased endothelial damage: Inflammatory mediators increase endothelial injury, not decrease it. B. Decreased inflammation: The mediators trigger and sustain inflammation, not reduce it. C. Decreased vascular permeability: This is the opposite of what occurs. Mediators cause capillary leak and edema. D. Increased vascular permeability: Inflammatory cytokines and mediators in SIRS lead to capillary leakage, allowing fluid and proteins to enter the interstitial space, contributing to tissue edema and organ dysfunction.