What serious adverse event should be watched for when prescribing Carbamazepine (Tegretol) to a patient for generalized tonic-clonic seizures?

A. Stevens-Johnson Syndrome: Carbamazepine is strongly associated with rare but serious dermatologic reactions, including Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN). These conditions present with widespread rash, mucosal lesions, and systemic symptoms, and require immediate discontinuation of the drug. B. Hepatitis: While carbamazepine can cause mild elevations in liver enzymes, clinically significant hepatitis is uncommon. Routine liver function monitoring is recommended, but this is not the primary serious adverse event of concern. C. Homicidal thoughts: Carbamazepine has mood-stabilizing effects and can cause CNS side effects, but homicidal ideation is rare. Monitoring for behavioral changes is advised, yet it is not the primary life-threatening risk. D. Megaloblastic anemia: Carbamazepine can rarely affect hematologic parameters, including leukopenia or thrombocytopenia, but megaloblastic anemia is not a typical adverse effect. Hematologic monitoring is recommended but SJS remains the most serious concern.