What therapeutic effects are expected with cholinergic agonists? Select all that apply.

Rationale: A. Decreased perspiration or sweating: Cholinergic agonists stimulate muscarinic receptors, which generally increase parasympathetic activity, including sweat gland stimulation. They do not decrease perspiration; in fact, sweating may be enhanced, so a decrease is not an expected. B. Enhanced glandular secretion: Activation of muscarinic receptors by cholinergic agonists increases secretions from exocrine glands, such as salivary, gastric, and bronchial glands. This effect is therapeutically beneficial in conditions like dry mouth or impaired digestive secretions. C. Increased gastrointestinal motility: Cholinergic agonists enhance parasympathetic stimulation of the gastrointestinal tract, increasing peristalsis and promoting digestion. This can be useful in treating conditions like postoperative ileus or constipation. D. Lacrimation or tear production: Cholinergic agonists stimulate lacrimal glands via muscarinic receptors, leading to increased tear production. This is therapeutically desirable in conditions like dry eyes or keratoconjunctivitis sicca. E. Increased heart rate: Cholinergic agonists primarily activate the parasympathetic nervous system, which typically slows the heart rate (negative chronotropic effect) rather than increasing it. An increase in heart rate is not an expected therapeutic effect.