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    Pharmacology proctored examQuestion 36
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    Pharmacology proctored exam

    What tricyclic may be prescribed for obsessive compulsive disorder?

    Explanation & Rationale

    A. Clomipramine: Clomipramine is a tricyclic antidepressant that strongly inhibits serotonin reuptake, making it particularly effective for treating obsessive-compulsive disorder (OCD). It was the first TCA approved for OCD. B. Doxepin: Doxepin primarily has antihistaminic and sedative effects and is more often used for depression with anxiety or insomnia, not OCD. C. Imipramine: Imipramine is mainly indicated for depression and sometimes enuresis but lacks the strong serotonergic action needed for OCD treatment. D. Nortriptyline: Nortriptyline is a secondary amine TCA with stronger norepinephrine than serotonin reuptake inhibition, making it less effective for OCD.

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