When a patient begins taking a selective serotonin-norepinephrine reuptake inhibitor such as venlafaxine (Effexor), what information should be included in the plan for patient education?

Choice A reason: This is incorrect. Salt intake is not typically restricted with SNRIs. This advice is more relevant for medications like lithium, which are affected by sodium balance and hydration status. Choice B reason: This is incorrect. While rare, twitching or jerking may indicate serotonin syndrome or other adverse effects, but it is not a routine or expected initial symptom. Patients should be educated about more common side effects such as nausea, headache, and insomnia. Choice C reason: This is correct. SNRIs like venlafaxine typically take 2–8 weeks to show full therapeutic effect. Educating patients about this delay helps set realistic expectations and promotes adherence. Choice D reason: This is incorrect. Tyramine restriction is necessary for patients taking monoamine oxidase inhibitors (MAOIs), not SNRIs. Venlafaxine does not interact with tyramine-containing foods.