When managing a patient with severe pain using hydromorphone, which of the following interventions should the nurse perform to prevent complications? (Select all that apply.)

Choice A reason: Monitoring respiratory rate is essential when administering hydromorphone, a potent opioid. Respiratory depression is a serious adverse effect, especially in opioid-naïve patients or those receiving high doses. Early detection of hypoventilation can prevent life-threatening complications. Choice B reason: Constipation is a common side effect of opioids due to decreased gastrointestinal motility. Regular assessment and proactive management with stool softeners or laxatives are necessary to prevent discomfort and complications such as fecal impaction. Choice C reason: Encouraging fluid intake helps mitigate opioid-induced constipation and supports overall hydration, which is important for maintaining renal function and preventing urinary retention. Choice D reason: Hydromorphone does not require administration with a high-calorie meal. Unlike some medications that cause gastric irritation, opioids are not food-dependent. This intervention does not prevent complications and may be misleading. Choice E reason: Limiting activity is not recommended unless the patient experiences severe dizziness or orthostatic hypotension. Encouraging safe mobility helps prevent complications such as deep vein thrombosis and promotes recovery. Choice F reason: NSAIDs can be used cautiously with opioids for multimodal pain management unless contraindicated. They do not interact directly with hydromorphone to cause complications, although they should be used carefully in patients with renal impairment or bleeding risk.