Which adverse effect unique to vancomycin is caused by histamine release?

A. Discoloration of body fluids: Discoloration of body fluids is commonly associated with rifampin, not vancomycin. B. Ototoxicity: Ototoxicity is a serious adverse effect of vancomycin, but it is not related to histamine release. It results from damage to the auditory nerve. C. Red-man syndrome: Red-man syndrome is a unique adverse effect of vancomycin characterized by flushing, rash, and pruritus, usually due to rapid infusion causing histamine release. It is not an allergic reaction but a direct effect of the drug. D. Nephrotoxicity: Nephrotoxicity is another serious adverse effect of vancomycin, but it is related to the drug's toxic effects on the kidneys, not histamine release.