Which are therapeutic effects of acetaminophen? Select all that apply.

A. Antacid: Acetaminophen does not neutralize stomach acid or alter gastric pH. Antacid properties are unrelated to its mechanism of action, which is focused on central inhibition of prostaglandin synthesis rather than gastrointestinal acid modulation. B. Anti-inflammatory: Unlike NSAIDs, acetaminophen has minimal to no peripheral anti-inflammatory effect. It primarily acts centrally in the CNS, reducing pain perception and fever without significant impact on inflammatory processes. C. Analgesic: Acetaminophen provides pain relief by inhibiting central prostaglandin synthesis, which decreases the perception of pain. It is effective for mild to moderate pain, such as headaches, musculoskeletal pain, and postoperative discomfort. D. Antidiarrheal: Acetaminophen does not affect gastrointestinal motility or secretions and therefore has no role in treating diarrhea. Its pharmacologic effects are limited to analgesia and fever reduction. E. Antipyretic: Acetaminophen reduces fever by acting on the hypothalamic heat-regulating center, promoting vasodilation and sweating. This thermoregulatory effect helps lower elevated body temperature in febrile conditions.