Which aspect of pharmacokinetics should the nurse be most concerned with when caring for a patient with abnormal functioning of hepatic enzymes?.

Choice A rationale: Absorption is not primarily affected by the functioning of hepatic enzymes. Choice B rationale: Distribution is not the main concern when dealing with abnormal functioning of hepatic enzymes. Choice C rationale: Excretion is mainly a function of the kidneys, not the liver. Choice D rationale: Metabolism is the aspect of pharmacokinetics most affected by the functioning of hepatic enzymes. The liver plays a crucial role in the metabolism of drugs.