Which class of drugs is considered first-line treatment for Restless Leg Syndrome/Willis-Ekbom disease?

A. Dopamine agonists: Dopamine agonists, such as pramipexole and ropinirole, are considered first-line therapy for restless leg syndrome (RLS). They bind to dopamine receptors in the CNS, reducing sensory and motor symptoms, particularly the urge to move the legs during rest or at night. B. Benzodiazepines: Benzodiazepines may be used as adjunct therapy to improve sleep in RLS, but they do not directly address the dopaminergic dysfunction causing the leg sensations. They are not first-line treatment. C. Psychostimulants: Psychostimulants are rarely used and may worsen RLS symptoms or insomnia. They are not recommended as a primary therapy due to side effect profiles and limited efficacy. D. Opioids: Opioids are reserved for severe or refractory RLS when first-line therapies fail. They carry risks of dependence, sedation, and constipation, so they are not considered first-line agents.