Which complication happens to the sickle-shaped red blood cells during a sickle cell crisis?

A. Production of hemoglobin S: Hemoglobin S is the cause of the sickling, not a complication that happens during the crisis. B. Rupture: While sickle cells do have a shorter lifespan (hemolysis), the primary "crisis" mechanism is related to their shape and rigidity. C. Interference with blood production: The crisis is a peripheral blood issue, not a failure of the bone marrow to produce cells. D. Obstruction of major arteries: The rigid, sickle-shaped cells clump together and block small blood vessels (vaso-occlusion), leading to tissue ischemia and intense pain.