Which factors predominantly determine probable diagnosis of multiple sclerosis (MS)?

A. Muscle biopsies are not used to diagnose MS; they are more relevant in diagnosing muscle disorders, not central nervous system demyelination. B. There are no definitive blood markers specific to MS; blood tests are mainly used to rule out other conditions. C. A lumbar puncture may support a diagnosis by revealing oligoclonal bands or inflammatory markers, but it is not the primary determinant. D. The diagnosis of MS is largely clinical, based on a combination of the patient’s history, reported symptoms (such as vision problems, weakness, and numbness), and neurological examination findings, often supported by MRI and other tests.