Which food-drug interaction is the nurse trying to prevent when instructing a patient with Parkinson's disease who has been prescribed selegiline to avoid wine and cheese?
Explanation & Rationale
A. Hypertrophy: Hypertrophy refers to an increase in tissue or organ size and is not related to food-drug interactions with selegiline. Consuming wine and cheese does not cause tissue enlargement but can trigger vascular complications instead. B. Hypertension: Selegiline is a monoamine oxidase-B (MAO-B) inhibitor. When combined with tyramine-rich foods such as wine and cheese, it can lead to a hypertensive crisis. Tyramine causes vasoconstriction and increased blood pressure when its breakdown is inhibited by the drug. C. Hyperglycemia: Elevated blood glucose levels are not associated with the interaction between selegiline and tyramine-containing foods. Selegiline does not significantly affect glucose metabolism, so hyperglycemia is not a concern in this context. D. Hyperthyroidism: Hyperthyroidism results from overactive thyroid hormone production and is not related to selegiline use or food interactions. Wine and cheese intake while on selegiline does not influence thyroid function.