Which information will the nurse give when advising a patient on what to do to avoid the development of tolerance to nitroglycerin?

A. Use the sublingual form only. Sublingual is for acute relief; using only that does not prevent tolerance to continuous nitrate therapy and is not practical for chronic prophylaxis. B. Store the drug in a dark container, free from light and moisture. Proper storage preserves potency but does not prevent physiologic tolerance from continuous exposure. C. Allow for a daily 8- to 12-hour nitrate free period. A daily nitrate-free interval (usually overnight) reduces development of tolerance to nitrates used chronically. D. Administer subsequent doses parenterally. Changing route does not prevent tolerance; continuous exposure by any route can still lead to tolerance.