Which medical history information is significant to potential bleeding problems? (Select all that apply.)

A. Takes NSAIDs four times a day: NSAIDs (like Ibuprofen) inhibit platelet aggregation and can cause gastric ulcers, significantly increasing the risk of bleeding. B. Eats red meat three times a week: This is a source of iron and B12; it does not increase bleeding risk. C. Had a cardiac valve replaced 6 months earlier: Patients with mechanical heart valves are almost always on long-term anticoagulant therapy (like Warfarin), which poses a high bleeding risk. D. Has hepatitis B: The liver produces clotting factors. Any hepatitis or liver disease can impair the production of these factors, leading to coagulopathy. E. Drinks two glasses of wine a day: While chronic alcoholism affects the liver, moderate wine consumption (2 glasses) is generally not the primary risk factor compared to NSAIDs or liver disease, though it can have mild anti-platelet effects.