Which of the following antidepressants is approved for use in children ages 8 and older?

A. Sertraline (Zoloft): Sertraline is an SSRI approved for pediatric obsessive-compulsive disorder (OCD) in children, but it is not FDA-approved for depression in children younger than 12. Its use for depressive disorders in younger children is off-label. B. Fluoxetine (Prozac): Fluoxetine is an SSRI approved for the treatment of major depressive disorder in children aged 8 years and older. It has demonstrated efficacy and safety in pediatric populations and is considered first-line for childhood depression. C. Bupropion (Wellbutrin): Bupropion is generally approved for adults with depression and is not FDA-approved for pediatric patients. Its use in children is off-label and requires caution due to seizure risk. D. Venlafaxine (Effexor): Venlafaxine is an SNRI approved for adults but not for children under 18. Pediatric use carries increased risk of side effects such as hypertension and suicidal ideation, so it is not considered first-line for children.