Which of the following are common age-related changes in the endocrine system? Select all that apply:

A. Reduced sensitivity to hormonal feedback: Aging decreases the responsiveness of target tissues to hormones, leading to altered feedback mechanisms. This diminished sensitivity contributes to slower metabolic regulation and impaired adaptation to physiological changes such as stress or glucose fluctuations. B. Decreased hormone concentrations: Many endocrine hormones, including estrogen, testosterone, growth hormone, and thyroid hormones, decline with age. Lower hormone levels affect metabolism, bone density, and muscle strength, contributing to common geriatric health challenges such as fatigue and decreased vitality. C. Increased number of hormone receptors: Aging typically results in a decline rather than an increase in receptor numbers and sensitivity. Fewer or less responsive receptors contribute to reduced hormonal effectiveness even when hormone levels remain adequate. D. Decreased function of endocrine glands: The endocrine glands, such as the thyroid, pancreas, and adrenal glands, gradually lose functional efficiency with age. This decline leads to slower hormone synthesis and secretion, affecting homeostatic balance and increasing the risk of metabolic disorders. E. Hyperplasia of the prostate gland: Prostate enlargement is a common age-related change in men, but it is not an endocrine change. It is a localized structural change related to cellular proliferation in the prostate, not a systemic alteration in hormonal regulation or glandular function.