Which of the following describes a clinical feature of non-opioid analgesics?

A. They are often addictive: Non-opioid medications do not have the potential for psychological addiction because they do not activate the reward centers of the brain. They lack the mu-receptor agonism responsible for the cravings and compulsive use associated with opioids. This makes them ideal for patients with a history of substance abuse. B. Primarily used for neuropathic pain: Neuropathic pain usually requires adjuvant medications like gabapentinoids or tricyclic antidepressants to stabilize nerve membranes. Non-opioids are most effective for inflammatory or musculoskeletal pain. While they can be part of a multimodal plan, they are not the primary treatment for nerve damage. C. Result in respiratory depression: One of the greatest safety advantages of non-opioids is that they do not depress the respiratory center in the medulla. Even at high doses, they do not cause the life-threatening bradypnea associated with opioid toxicity. Their primary risks involve gastrointestinal, renal, or hepatic toxicity instead. D. Useful for mild to moderate pain: Non-opioid analgesics, such as acetaminophen and NSAIDs, provide effective relief for nociceptive pain without the risk of physical dependence. Unlike opioids, they do not produce euphoria or a "high," making them safer for long-term use in non-malignant pain. They are the first step on the WHO pain ladder.