Which of the following drugs is indicated to use in generalized anxiety disorder (GAD)? SELECT THREE

A. Mirtazapine (Remeron): Mirtazapine is primarily indicated for major depressive disorder and is not considered a first-line treatment for generalized anxiety disorder. Its sedative effects may help with sleep disturbances but do not address core anxiety symptoms consistently. B. Sertraline (Zoloft): Sertraline is a selective serotonin reuptake inhibitor (SSRI) approved for GAD. It reduces anxiety by increasing serotonergic neurotransmission, improving mood regulation, and decreasing worry and tension over several weeks of consistent dosing. C. Escitalopram (Lexapro): Escitalopram, another SSRI, is FDA-approved for GAD. It effectively alleviates persistent anxiety and somatic symptoms through selective serotonin reuptake inhibition and is considered a first-line pharmacologic option. D. Venlafaxine (Effexor): Venlafaxine is a serotonin-norepinephrine reuptake inhibitor (SNRI) approved for GAD. It modulates both serotonin and norepinephrine pathways, providing significant reduction in anxiety, restlessness, and associated somatic complaints.